Molecular mechanisms of cardiomyocyte aging

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Molecular mechanisms of cardiomyocyte aging.

Western societies are rapidly aging, and cardiovascular diseases are the leading cause of death. In fact, age and cardiovascular diseases are positively correlated, and disease syndromes affecting the heart reach epidemic proportions in the very old. Genetic variations and molecular adaptations are the primary contributors to the onset of cardiovascular disease; however, molecular links between...

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Vascular aging plays an important role in the mortality of the elderly, but vascular aging can be dependent on other factors such as diseases. Various diseases such as Alzheimer, diabetes, thalassemia, and other diseases affect the mechanisms of vascular aging. It will harm the recovery process of these patients. There are methods for measuring vascular aging such as instrumental measurements a...

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Molecular mechanisms of cardiac aging

Corresponding author: Dr. Zhou Tianjun, MD, Ph.D, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9038, USA.; E-mail: [email protected] Abstract Age-associated changes in cardiovascular structure/ function are implicated in the markedly increased risk for cardiovascular disease in older persons. Aging not only prolongs exposure to ...

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Review of Mechanisms and Theories of Aging

Several factors have incentive role for study of aging which includes increasing of the average and maximum of human life span, the increase in percentage of elderly in the societies and proportion of the national expenditure utilized by them. The Recent views of aging indicating that aging is extremely a complex multifactorial process despite of earlier views about definite cause aging like ge...

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We have recently defined nine molecular and cellular hallmarks that represent common denominators of aging in different organisms. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. On the other hand...

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ژورنال

عنوان ژورنال: Clinical Science

سال: 2011

ISSN: 0143-5221,1470-8736

DOI: 10.1042/cs20110115